Journal Club: The impact of elevated triglycerides on cardiovascular and other diseases

See the Journal Club page for more information.

Topic: The impact of elevated triglycerides on cardiovascular and other diseases

1. Read, and review through discussion, information regarding the relationship of triglyceride and high-cholesterol in heart disease and type 2 Diabetes

* Vega GL, Barlow CE, Grundy SM, et al Triglyceride–to–high-density-lipoprotein-cholesterol ratio is an index of heart disease mortality and of incidence of type 2 diabetes mellitus in men. Journal of Investigative Medicine 2014;62:345-349.

Downloaded http://jim.bmj.com/1 July 2018

2. Discuss the relationship of triglyceride to all-cause mortality, as well as potential preventive measures

* Robert K, Aharon E, Ben-Zekry S, Goldenberg I, Fisman E et al. Elevated triglyceride level is independently associated with increased all-cause mortality in patients with established coronary heart disease: Twenty-two–year follow-up of the Bezafibrate Infarction Prevention Study and Registry. Circ Cardiovasc Qual Outcomes. 2016; 9:100-108. DOI: 10.1161/

* Karon A. High triglycerides linked to mortality in coronary heart disease Cardiology News. Publish date: March 8, 2016

* Singh AW, Singh R. Triglyceride and cardiovascular risk: A critical appraisal. Indian J Endocrinol Metab. 016 Jul-Aug; 20(4): 418–428. doi: 10.4103/2230-8210.183460 PMCID: PMC4911828 PMID: 27366705

3. Discuss (compare and contrast) the impact of 2 dietary interventions on cardiovascular risk, morbidity, and mortality

* Sofi F, Din M, Pagliai G, Cesari F, et al. Low-calorie vegetarian versus mediterranean diets for reducing body weight and improving cardiovascular risk profile. CARDIVEG Study (Cardiovascular Prevention With Vegetarian Diet). Circulation. 2018;137:1103–1113. DOI: 10.1161/CIRCULATIONAHA.117.030088. March 13, 2018